the effect of forced physical exercise with moderate intensity on alzheimer-induced amnesia in adult male rats

the aim of this study was to investigate the effect of forced physical exercise with moderate intensity on alzheimer-induced amnesia in adult male rats. 48 male wistar- albino rats were randomly selected and assigned to 6 groups (n=8 per group): control, placebo (saline), drug-exercise, saline-exercise, exercise and exercise-drug. in this study, dicyclomine (16 mg/kg) was used to induce alzheimer-like amnesia and moderate exercise (60 minutes per day × 30 days). the rats were trained and tested using morris water maze­. the findings showed that the group receiving dicyclomine increased­ delay in reaching the platform­ in acquisition (p=0.044) and recall (p=0.031) compared with exercise, control and saline groups. but there were no significant differences between exercise and exercise-saline groups compared with exercise-dicyclomine group. also, a significant difference (delay in reaching the platform) was observed between dicyclomine-exercise, saline-exercise compared with dicyclomine in acquisition (p=0.005) and recall (p=0.002). in conclusion, this study showed that memory and learning in the acquisition and recall phases were destroyed by dicyclomine and 30 sessions of moderate-intensity running (forced) could prevent memory corruption.